Neuropeptide S receptor in GtoPdb v.2023.1
نویسندگان
چکیده
The neuropeptide S receptor (NPS receptor) responds to the 20 amino-acid peptide derived from a precursor (NPS, P0C0P6). NPS activates its at low nanomolar concentrations elevating intracellular cAMP and calcium levels [71]. Currently, some peptidic small molecule antagonists are available as research tools [27, 79, 8, 59]. No ligands currently used clinically.
منابع مشابه
Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor.
Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), can regulate a variety of biological functions, including arousal, anxiety, locomotion, memory and drug abuse. Previous studies have shown that central NPS inhibited food intake in rats and chicks. In the present study, we investigated the role of central NPS on food intake in fasted mice, and detected the underlying mechanism(...
متن کاملNeuropeptide S- and Neuropeptide S receptor-expressing neuron populations in the human pons
Neuropeptide S (NPS) is a regulatory peptide with potent pharmacological effects. In rodents, NPS is expressed in a few pontine cell clusters. Its receptor (NPSR1) is, however, widely distributed in the brain. The anxiolytic and arousal-promoting effects of NPS make the NPS-NPSR1 system an interesting potential drug target in mood-related disorders. However, so far possible disease-related mech...
متن کاملMolecular Evolution of the Neuropeptide S Receptor
The neuropeptide S receptor (NPSR) is a recently deorphanized member of the G protein-coupled receptor (GPCR) superfamily and is activated by the neuropeptide S (NPS). NPSR and NPS are widely expressed in central nervous system and are known to have crucial roles in asthma pathogenesis, locomotor activity, wakefulness, anxiety and food intake. The NPS-NPSR system was previously thought to have ...
متن کاملIn vitro and in vivo pharmacological characterization of the neuropeptide s receptor antagonist [D-Cys(tBu)5]neuropeptide S.
Neuropeptide S (NPS) was identified as the endogenous ligand of an orphan receptor now referred to as the NPS receptor (NPSR). In the frame of a structure-activity study performed on NPS Gly5, the NPSR ligand [D-Cys(tBu)(5)]NPS was identified. [D-Cys(tBu)(5)]NPS up to 100 microM did not stimulate calcium mobilization in human embryonic kidney (HEK) 293 cells stably expressing the mouse NPSR; ho...
متن کاملIn Vitro and in Vivo Pharmacological Characterization of the Neuropeptide S Receptor Antagonist [D-Cys(tBu)]Neuropeptide S
Neuropeptide S (NPS) was identified as the endogenous ligand of an orphan receptor now referred to as the NPS receptor (NPSR). In the frame of a structure-activity study performed on NPS Gly5, the NPSR ligand [D-Cys(tBu)]NPS was identified. [D-Cys(tBu)]NPS up to 100 M did not stimulate calcium mobilization in human embryonic kidney (HEK) 293 cells stably expressing the mouse NPSR; however, in a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: IUPHAR/BPS guide to pharmacology CITE
سال: 2023
ISSN: ['2633-1020']
DOI: https://doi.org/10.2218/gtopdb/f44/2023.1